I can't imagine the older MLS teams are going to play Murietta Surf, Chula Vista, Santa Barbara SC, etc. It would be completely pointless unless they had the MLS u17's play the u19 teams of those clubs.
Yes it would be a waste of time for the MLS teams to play some of the teams on that list.
The DA recognized that last year and separated the U19s into a weaker bracket and a stronger bracket.