Every web source I could find that had a positive opinion of PRP therapy was also selling it. Coincidence, right?
PRP has been investigated and used for chronic
tendinitis,
[1] osteoarthritis,
[2] in
oral surgery,
[3] and in
plastic surgery.
[4]
A 2015 meta-analysis on PRP for
osteoarthritis (OA) of the knee and found that nine were worth considering and concluded that with respect to short term outcomes, PRP was no better than placebo.
[5]
A 2009 review found few randomized controlled trials that adequately evaluated the safety and efficacy of PRP treatments and concluded that PRP was "a promising, but not proven, treatment option for joint, tendon, ligament, and muscle injuries".
[6]
A 2010 Cochrane analysis on PRP use in
sinus lifts during
dental implant placement found no evidence that PRP offered any benefit.
[3]
A 2013 review stated more evidence was needed to determine PRP's effectiveness for hair regrowth.
[7]
A 2014 Cochrane review of PRP use in musculoskeletal injuries found very weak evidence for a decrease in pain in the short term, and no difference in function in the short, medium or long term. There was weak evidence that suggested that harm occurred at comparable, low rates in treated and untreated people.
[8]Similarly, another 2017 review for treating pain on skin graft donor sites found the evidence for benefit was poor.
[9]
It has not been shown to be useful for bone healing.
[10] A 2016 review of PRP use to augment bone graft found only one study reporting a difference in bone augmentation, while four studies found no difference.
[11]
Since 2004, proponents of PRP therapy have argued that negative clinical results are associated with poor-quality PRP produced by inadequate
single spin devices. The fact that most gathering devices capture a percentage of a given thrombocyte count could bias results, because of inter-individual variability in the platelet concentration of human plasma and more would not necessarily be better.
[12]
PRP is also being injected into the
vagina, in a procedure called "O-shot" or "orgasm shot" with claims that this will improve
orgasms.
[13] There is no evidence, however, to support these claims.
[13]